HYDROGELS AS NOVEL ALTERNATIVE FOR THE MANAGEMENT OF VARIOUS DISEASES OF CENTRAL NERVOUS SYSTEM

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Abstract :

The word 'Hydrogel' includes 'Hydro' and 'Gel' indicating gel like property and watersolubility. Hydrogel formation includes combining together of monomer units to form cross linked structure which provides water insolubility. Hydrogel as a delivery system has gained wide acceptability due to its various applications. Based on the monomer used, hydrogel possess different properties and can be used for various diseases and disorders. Materials used for hydrogel formulation include Polyvinyl alcohol (PVA), Polyethylene oxide (PEO) and polysaccharides such as Chitosan, Cellulose, Agarose, Carragenan. Depending on the swelling behaviour, hydrogel can be used for different applications including controlled relase formulations The classification of hydrogel is based on the its physical, chemical, swelling, and source. Hydrogel based delivery system has application in effective management of various diseases of central nervous system like Alhzeimer; Parkinson's; Tumor of spinal cord; Down's syndrome and brain stroke. Different materials used in the formulation of the hydrogel provide different property thus making it suitable for management of different diseases and disorders besides central nervous system.