CHEMOMETRIC ASSISTED SPECTROPHOTOMETRIC TECHNIQUES FOR SIMULTANEOUS DETERMINATION OF AMLODIPINE BESYLATE AND TELMISARTAN IN MARKETED TABLET FORMULATION

Author : Khushboo Khatri, Prachi R. Bhamre and S. J. Rajput*

Page Nos : 57 - 69

Abstract :

Chemometric assisted spectrophotometry and HPLC methods have been developed for the simultaneous determination of Amlodipine besylate and Telmisartan. The two chemometric methods i.e. Inverse least square (ILS) and Classical least square (CLS) methods were successfully applied to quantify each drug in the mixture using the information included in the UV absorption spectra of appropriate solutions in the range of 230-302 nm with the intervals of 4 nm at 19 wavelengths. The HPLC method was developed and the three methods (ILS, CLS and HPLC) were successfully applied to marketed formulation and the results were compared statistically which showed no significant difference among the results.